Published August 1987
| Version v1
Journal article
In vitro IgM and IgM rheumatoid factor production in response to Staphylococcus aureus Cowan I: evidence for the role of Leu-2-positive T suppressor cells and radiosensitive T helper cells
Creators
- 1. Ottawa General Hospital (Canada). Div. of Rheumatology and Clinical Immunology
- 2. Laboratory Centre for Disease Control, Ottawa (Canada)
Description
Staphylococcus aureus Cowan 1 (SAC) is a potent stimulus of B cell proliferation and differentiation, the latter being T cell-dependent. It has been suggested that immunoglobulin and IgM rheumatoid factor (RF) production in response to SAC involves radiosensitive T helper cells. We studied normal peripheral blood mononuclear cell (PBMC) cultures to assess the roles of radiosensitive T cells and Leu-2 positive suppressor cells in the cellular control of SAC-stimulated IgM and IgM RF responses. (author)
Additional details
Publishing Information
- Journal Title
- Clin. Exp. Immunol.
- Journal Volume
- 69
- Journal Issue
- 2
- Series
- Clin. Exp. Immunol.
- Journal Page Range
- 358-367
- ISSN
- 0009-9104
- CODEN
- CEXIA
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 19001346
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BLOOD CELLS; CELL CULTURES; IMMUNE REACTIONS; IMMUNOGLOBULINS; IMMUNOSUPPRESSION; IN VITRO; MAN; RHEUMATIC DISEASES; STAPHYLOCOCCUS
- Descriptors DEC
- ANIMALS; BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; DISEASES; GLOBULINS; MAMMALS; MATERIALS; MICROORGANISMS; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; RADIATION EFFECTS; SKELETAL DISEASES; VERTEBRATES