Published November 2018
| Version v1
Journal article
Synthesis and evaluation of an N-[18F]fluorodeoxyglycosyl amino acid for PET imaging of tumor metabolism
Creators
- 1. Molecular Imaging Precision Medical Collaborative Innovation Center, Shanxi Medical University, Taiyuan (China)
- 2. Department of Radiology, Massachusetts General Hospital, Boston (United States)
- 3. Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan (China)
- 4. Shanxi Medical University, Taiyuan (China)
Description
The limitations of [18F]fluorodeoxyglucose ([18F]FDG), including producing false-positive or -negative results, low image contrast in brain tumor diagnosis and poor differentiation of tumor and inflammatory, necessitate the development of new radiopharmaceuticals. In the present study, a novel [18F]fluoroglycoconjugate tracer, [18F]FDGly-NH-Phe, for tumor metabolism imaging was prepared and evaluated.
Additional details
Identifiers
- DOI
- 10.1016/j.nucmedbio.2018.08.002;
- PII
- S0969805118301057;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 66
- Journal Page Range
- p. 40-48
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55042912
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AMINO ACIDS; BRAIN; DIAGNOSIS; EVALUATION; FLUORINE 18; FLUORODEOXYGLUCOSE; IMAGES; INFLAMMATION; METABOLISM; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SYNTHESIS
- Descriptors DEC
- ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPTOMS; TOMOGRAPHY
Optional Information
- Copyright
- Copyright (c) 2018 Elsevier Inc. All rights reserved.