Obtainment and characterization of nanocomposites for pharmaceutical applications

Many studies use the concept of nanocomposites for pharmaceutical applications, more specifically use as excipients. A nanocomposite PVP - lamellar silicate (organoclay) was prepared by solution in toluene. In this work, a scanning time of reaction was performed using different amplitudes obtained by a sonicator in different proportions of organoclay to characterization through X-ray diffraction (XRD). The analysis suggests the formation of nanocomposites with evidence of exfoliation, a result attributed to the possible disruption caused by different ultrasonic vibrations on the lamellar structure of clay that were able to destabilize the negatively charged lamellae. (author)