Published 1982 | Version v1
Journal article Metadata-only

Phenformin-inhibition of radiation carcinogenesis in female rats

Creators

  • 1. Tsentral'nyj Nauchno-Issledovatel'skij Rentgeno-Radiologicheskij Inst., Leningrad (USSR)
  • 2. Nauchno-Issledovatel'skij Inst. Onkologii, Leningrad (USSR)

Description

The increase of the sensitivity threshold of hypothalamo-hypophysial complex to the inhibition of hypothalamo-hypophysial complex with estrogenes, while inhibition with estrogenes-hyperglycemia, hyperinsulinemia, and hyperglyceridrmia, is established 6 momenths afteu irradiation of female rats in the dose of 4 Gr. In 78% of irradiated rats neoplasms of different localization are noted. The introduction of phenphormine within the whole period of life started at the day following irradiation reduced 1.6 times the frequency of tumour development, mainly hypophysis and mammary glands. It is supposed that antitumour effect of phenphormine is caused by its normalizing effect on harmonal metabolic shifts induced by irradiation

Additional details

Additional titles

Original title (Russian)
Tormozhenie fenforminom radiatsionnogo kantserogeneza u samok krys

Publishing Information

Journal Title
Ehksp. Onkol.
Journal Volume
4
Journal Issue
6
Series
Ehksp. Onkol.
Journal Page Range
26-29
ISSN
0204-3564

INIS

Country of Publication
Ukraine
Country of Input or Organization
USSR
INIS RN
15030795
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOCHEMICAL REACTION KINETICS; BIOLOGICAL LOCALIZATION; CARCINOGENESIS; DELAYED RADIATION EFFECTS; DRUGS; FEMALES; HOMEOSTASIS; HYPERGLYCEMIA; METABOLISM; NEOPLASMS; POST-IRRADIATION THERAPY; RADIATION INJURIES; RATS; X RADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; DISEASES; ELECTROMAGNETIC RADIATION; INJURIES; IONIZING RADIATIONS; KINETICS; MAMMALS; MEDICINE; PATHOGENESIS; RADIATION EFFECTS; RADIATIONS; REACTION KINETICS; RODENTS; THERAPY; VERTEBRATES