Effects of chronic renal dysfunction on severity of coronary artery disease and outcome of PTCA

Objective: The study assesses the effects of chronic renal dysfunction on severity of coronary disease and outcomes of percutaneous coronary intervention. Methods: Twenty five patients with serum creatinine > 150 μmol/L who underwent PTCA and/or coronary stenting were included (renal dysfunction group). Another 25 age-and sex-matched patients who had normal serum creatinine level and received coronary intervention at the same period were served as a control group. The status of coronary disease, procedural complications and long-term prognosis were compared between the two groups. Results: The number of patients with multi-vessel disease (72% VS 48%, p < 0.05), especially triple vessel disease (44% vs 12%, P < 0.05) and overall complication rate during the procedure (44% vs 16%, P < 0.05) were significantly higher in renal dysfunction group than in control group. During follow-up, patients in renal dysfunction group had higher recurrence rate of chest pain (44% vs 16%, P < 0.05). Two patients in renal dysfunction group died but none in control group. Conclusions: Patients with chronic renal dysfunction usually had severe coronary disease, experienced more complications during intervention procedure and poor long-term outcomes