Effect of different types of blood purification treatment (HD and HDF) on the serum PTH, leptin and Hcy levels in patients with chronic renal failure

Objective: To investigate the effect of different type of blood purification treatment (hemodialysis and hemodiafiltration) on the serum PTH, Leptin and Hcy levels in patients with chronic renal failure(CRF). Methods: Serum levels of PTH(with ECLIA), Leptin(with RIA) and Hcy(with biochemistry) were measured in 30 patients treated with hemodialysis(HD) and 30 patients treated with hemodiafiltration(HDF) both before and after treatment. Results: The concentration of PTH decreased significantly from 60.8±32.5pmol/L to 28.2±17.2pmol/L in patients treated with HDF(P<0.01). The concentration of leptin significantly decreased from (19.7±11.8) μg/L to(14.1±10.6) μg/L(P<0.05)and the concentration of Hcy also decreased significantly from 32.3±10.7μmol/L to 21.1±8.9μmol/L (P<0.01) in patients treated with HDF. The concentration of PTH decreased significantly from 61.6±30.8pmol/L to 42.2±16.5pmol/L in patients treated with HD(P<0.05). The concentration of leptin decreased only in significantly from(19.3±12.1)μg/L to(18.9±12.3)μg/L(P>0.05). Yet the concentration of Hcy also decreased significantly from 31.5μ10.5μmol/L to 20.4±8.5μmol/L(P<0.01) in patients treated HD. Conclusion: HDF can eliminate serum PTH, leptin and Hcy better than HD does. (authors)