Published October 7, 2005
| Version v1
Journal article
Beyond the Bragg Peak: Hyperthermal Heavy Ion Damage to DNA Components
- 1. Ion Reaction Laboratory, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4 (Canada)
Description
We have observed the destruction of fundamental building blocks of DNA (nucleoside, base, and sugar) by hyperthermal (0.25-1.75 eV/amu) heavy ion impact. Nucleoside damage pathways include base or sugar loss, and complete disintegration of either moiety. Sugar damage dominates, and in DNA will yield a complex strand break. Our results suggest that (a) heavy particle damage to biological media may extend to ion track ends beyond the Bragg peak, and (b) the nascent damage by hyperthermal secondary heavy particles, formed along the primary ion tracks, may be equally complex
Additional details
Identifiers
Publishing Information
- Journal Title
- Physical Review Letters
- Journal Volume
- 95
- Journal Issue
- 15
- Journal Page Range
- p. 153201-153201.4
- ISSN
- 0031-9007
- CODEN
- PRLTAO
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 37012454
- Subject category
- S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BRAGG CURVE; DNA; HEAVY IONS; ION BEAMS; NUCLEAR DAMAGE; NUCLEOSIDES; PARTICLE TRACKS; SACCHAROSE; STRAND BREAKS
- Descriptors DEC
- BEAMS; BIOLOGICAL EFFECTS; CARBOHYDRATES; CHARGED PARTICLES; DIAGRAMS; DISACCHARIDES; DNA DAMAGES; INFORMATION; IONS; NUCLEIC ACIDS; NUCLEOTIDES; OLIGOSACCHARIDES; ORGANIC COMPOUNDS; RADIATION EFFECTS; RIBOSIDES; SACCHARIDES
Optional Information
- Notes
- (c) 2005 The American Physical Society