The role of the dose of adjuvant radiation therapy for uterine sarcomas stage I–II

The postoperative radiotherapy course was performed on 106 patients with uterine sarcoma stage I–II (T1a–2NxM0), which were divided into two groups – radiotherapy alone in TFD 40-50 Gy, and in combination with brachytherapy (boost) in TFD up to 60-70 Gy. Conducting postoperative irradiation with a dose of 70-80 Gy due to brachytherapy on the tumor bed contributes to a decrease in the incidence of local recurrence: 41.9 versus 24.5 % regardless of the treatment regimen. Conducting radiotherapy in the combined regimen provides the absence of relapse and a reduction in the frequency of metastasis from 66.7 to 11.8 %. An increase in the dose of irradiation in complex treatment is likely to reduce the rate of relapse from 25.0 to 6.3 %, and metastases – from 75.0 to 25.0 %, especially in stage I — from 33.3 to 7.1%. The dose of adjuvant radiation therapy is a factor that affects the incidence of relapse and metastasis.