Progress on research of radioisotope-labeled porphyrin derivatives

Porphyrin derivatives can be taken up by tumor cells and accumulated there for a long time. Since 1960's, radioactive isotope-labeled porphyrins have been under extensive researches around the world. The progress of labeled porphyrins with various radioactive isotopes includes 3H, 11C, 123I, 131I, 99mTc, 188Re, 117,113mSn, 153Sm, 109Pd, 111In, 57Co, 58Co, 65Zn, 64,67Cu, 90Y, 166Ho is reviewed here. Among them, we studied the labeling conditions, chemical and biochemical properties of 188Re-labeled, 117,113mSn-labeled and 153Sm-labeled T3,4CPP and TPPS4. We also studied the bio-distribution of 188Re-labeled T3,4CPP and TPPS4 in mice with transplanted liver tumor and melanoma. Other researches in porphyrins which could affect the research of radioisotope-labeled porphyrins are introduced in the end. This review could provide a reference for design of better radioisotope-labeled porphyrins. (authors)