An alternative synthesis of DL-[l-11C]alanine from [11C]HCN
Creators
- 1. Turku Univ. (Finland)
- 2. Aabo Akademi, Turku (Finland)
Description
The synthesis of DL-[1-11C]alanine from [11C]HCN via DL-[1-11C]2-aminopropanenitrile and its use in an enzymatic synthesis of [1-11C]pyruvic acid is reported. The purified DL-[1-11C]alanine was obtained in a radiochemical yield of 75% with a radiochemical purity higher than 98% within 40 min after end of bombardment (EOB). [1-11C]Pyruvic acid was prepared by enzymatic synthesis from crude DL-[1-11C]-alanine using a previously reported procedure for the synthesis of [3-11C]pyruvic acid. DL-[1-11C]Alanine and [1-11C]pyruvic acid prepared by these methods have been found to be sterile and free of pyrogens, and can thus be used in studies of the distribution of these radiopharmaceuticals in man using positron emission tomography (PET). (author)
Additional details
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 41
- Journal Issue
- 12
- Series
- Appl. Radiat. Isot.
- Journal Page Range
- 1187-1191
- ISSN
- 0883-2889
- CODEN
- ARISE
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 22025258
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ALANINES; CARBON 11; CHEMICAL PREPARATION; ENZYMES; HYDROCYANIC ACID; LABELLING; POSITRON COMPUTED TOMOGRAPHY; PYRUVIC ACID; RADIOPHARMACEUTICALS
- Descriptors DEC
- AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HYDROGEN COMPOUNDS; INORGANIC ACIDS; INORGANIC COMPOUNDS; ISOTOPES; KETO ACIDS; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY