Published 2004 | Version v1
Journal article Metadata-only

Genetic action of radiation with different physical characteristics on human and mammalian cells

Creators

  • 1. Ob''edinennyj Inst. Yadernykh Issledovanij, Dubna (Russian Federation)

Description

The induction of HPRT-mutations and the survival of Chinese hamster cells were studied after exposure to accelerated 4He and 12C ions with various LET (20-360 keV/μm) and to γ rays. The linear-quadratic dose-effect curves were observed after exposure to radiation with LET up to ∼50 keV/μm. The regularities of unstable chromosome aberration formation in human lymphocytes were studied after exposure to γ rays, protons and 12C, 24Mg, and 14N ions (LET∼0.218; ∼12; 42.7 and ∼77 keV/μm, respectively)

Abstract (Russian)

Исследована индукция HPRT-мутаций и выживаемость клеток китайского хомячка при облучении ускоренными ионами 4He и 12C (ЛПЭ 20-360 кэВ/мкм) и γ-квантами. Выявлена степенная зависимость частоты возникновения мутаций от дозы излучений с ЛПЭ до 50 кэВ/мкм. Изучены закономерности образования нестабильных хромосомных аберраций в лимфоцитах крови человека после облучения протонами, ионами 12C, 24Mg и 14N (ЛПЭ∼0.218; ∼12; 42.7 и ∼77 кэВ/мкм, соответственно)

Additional details

Additional titles

Original title (Russian)
Генетическое действие излучений с разными физическими характеристиками на клетки человека и млекопитающих

Publishing Information

Journal Title
Fizika Ehlementarnykh Chastits i Atomnogo Yadra
Journal Volume
35
Journal Issue
6
Journal Page Range
p. 1483-1511
ISSN
0367-2026
CODEN
FECAAR

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
36055195
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CARBON 12 BEAMS; CELL CULTURES; CHROMOSOMAL ABERRATIONS; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; GENETIC RADIATION EFFECTS; GENOME MUTATIONS; HAMSTERS; HELIUM 4 BEAMS; LET; LYMPHOCYTES; MEN; MUTATION FREQUENCY; RBE; SURVIVAL CURVES
Descriptors DEC
ANIMAL CELLS; ANIMALS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; ENERGY TRANSFER; GENETIC EFFECTS; ION BEAMS; IONIZING RADIATIONS; LEUKOCYTES; MALES; MAMMALS; MAN; MATERIALS; MUTATIONS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES

Optional Information

Notes
85 refs.; 4 tabs.; 15 figs.