Published January 1992
| Version v1
Journal article
Analysis of 99mTc-labeled radiopharmaceuticals by high-performance liquid chromatography
Description
High-performance liquid chromatography (HPLC) equipped with on line radiometric and optical detectors have been applied to the radiochemical analysis of ten commonly-used 99mTc-radiopharmaceuticals with a view point to check the radiochemical purities of the compounds before use. Chromatographic conditions were determined by examination of the types of column and mobile phase. A gel filtration (Shim-pack DIOL-300) and reversed-phase column (Zorbax ODS) were found to be suitable for 99mTc-HSA and the other 99mTc-compounds, respectively. From these results, HPLC has been shown to be useful method for the analysis of 99mTc-radiopharmaceuticals, with rapidity and excellent precision. (author)
Additional details
Publishing Information
- Journal Title
- Radioisotopes (Tokyo)
- Journal Volume
- 41
- Journal Issue
- 1
- Series
- Radioisotopes (Tokyo).
- Journal Page Range
- 31-34
- ISSN
- 0033-8303
- CODEN
- RAISA
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 23038465
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- DTPA; LIQUID COLUMN CHROMATOGRAPHY; PYROPHOSPHATES; RADIOMETRIC ANALYSIS; RADIOPHARMACEUTICALS; TECHNETIUM 99; TIME DEPENDENCE; UPTAKE
- Descriptors DEC
- AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; CHEMICAL ANALYSIS; CHROMATOGRAPHY; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SEPARATION PROCESSES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES