Published 1990 | Version v1
Journal article Metadata-only

Activation of the anticancer drug CCNU into a free radical intermediate via UV irradiation--an ESR study

Creators

  • 1. Lab. of Molecular Oncology, Stara Zagora (Bulgaria)

Description

We studied the formation of a free radical induced by UV irradiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in benzene. It was determined a stable nitroxide radical by ESR spectroscopy. We confirmed that sterically hindered cyclic amine 2,2,6,6-tetramethyl-4-piperidone (TMPone) was transformed into a corresponding stable free nitroxyl radical during UV irradiation. When CCNU was present, the rate of free radical formation from TMPone increased considerably

Additional details

Publishing Information

Journal Title
Free Radical Biology and Medicine
Journal Volume
9
Journal Issue
5
Series
Free Radic. Biol. Med.
Journal Page Range
423-426
ISSN
0891-5849
CODEN
FRBME

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
22050607
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANTINEOPLASTIC DRUGS; BENZENE; CHEMICAL RADIATION EFFECTS; ELECTRON SPIN RESONANCE; RADIATION EFFECTS; RADICALS; ULTRAVIOLET RADIATION
Descriptors DEC
AROMATICS; DRUGS; ELECTROMAGNETIC RADIATION; HYDROCARBONS; MAGNETIC RESONANCE; ORGANIC COMPOUNDS; RADIATIONS; RESONANCE