Published November 2018 | Version v1
Journal article Metadata-only

Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

Creators

  • 1. Environmental Health Sciences Division, School of Public Health, University of California, Berkeley, CA (United States)
  • 2. Pontificia Universidad Católica de Chile, Advanced Center for Chronic Diseases, ACCDiS, Santiago (Chile)
  • 3. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA (United States)
  • 4. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA (United States)

Description

Highlights: • Northern Chile is one of the driest places on earth. • Historical arsenic water measurements allow for estimation of lifetime exposure. • Increased odds of type 2 diabetes with arsenic exposure observed. • Synergistic relationship between arsenic and obesity on type 2 diabetes identified. The prevalence of type 2 diabetes (T2D) has nearly doubled since 1980. Elevated body mass index (BMI) is the leading risk factor for T2D, mediated by inflammation and oxidative stress. Arsenic shares similar pathogenic processes, and may contribute to hyperglycemia and β-cell dysfunction.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.envres.2018.07.022

Additional details

Identifiers

DOI
10.1016/j.envres.2018.07.022;
PII
S0013935118303918;

Publishing Information

Journal Title
Environmental Research
Journal Volume
167
Journal Page Range
p. 248-254
ISSN
0013-9351
CODEN
ENVRAL

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53022335
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ARSENIC; BIOLOGICAL STRESS; CHILE; HEALTH HAZARDS; HYPERGLYCEMIA; INFLAMMATION; LIFETIME; METABOLIC DISEASES; OXIDATION
Descriptors DEC
CHEMICAL REACTIONS; DEVELOPING COUNTRIES; DISEASES; ELEMENTS; HAZARDS; LATIN AMERICA; PATHOLOGICAL CHANGES; SEMIMETALS; SOUTH AMERICA; SYMPTOMS

Optional Information

Copyright
Copyright (c) 2018 Elsevier Inc. All rights reserved.