Therapeutic effects by localization in patients with head and neck carcinoma, treated in the Radiotherapy Clinic in the period 2006-2015

For the period from the beginning of 2006 to the end of 2015, 353 patients with head and neck tumors were treated in the Radiotherapy Clinic, National Oncology Hospital, excluding the patients with tumors in the area of the lips, skin, thyroid and parotid gland. The patients were between 13 and 93 years, with an average age of 57.8. Of these, 268 (76%) were men and 85 (24%) were women. The patients were predominantly with advanced carcinomas in the III and IV clinical stages. In 133 (33%) patients, both radiotherapy and chemotherapy were performed. The therapeutic results by localization have been followed-up. Conclusion: Significant advantage of concomitant administration of radiotherapy treatment is the justification for its use as a standard in these difficult to treat tumors. The most pronounced contribution of radiation-chemotherapy is in carcinomas of the tongue, larynx, oral cavity and oropharynx. However, it is negligible in the case of hypopharynx, and with the opposite effect in epipharyngeal carcinoma. The administration of neoadjuvant chemotherapy shows an advantage in the therapeutic outcome in patients with advanced head and neck tumors. Our clinical experience in the early visible local control using simultaneous integrated boost (SIB) raises some questions about toxicity and application in not very well-defined functional areas.