Published April 2012 | Version v1
Journal article

Direct palladium-catalyzed C-4 arylation of tri-substituted furans with aryl chlorides: An efficient access to heteroaromatics

  • 1. College of Chemistry and Chemical Engineering/Hunan Institute of Engineering, Xiangtan (China)
  • 2. Guangdong Univ. of Education, Guangzhou (Korea, Republic of)

Description

A series of functionalized furans were synthesized by way of a palladium -catalyzed coupling reaction of 2,3,5-tri substituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of BuAd2P and t-BuOK in DMF at 120 .deg. C after 15 h

Additional details

Publishing Information

Journal Title
Bulletin of the Korean Chemical Society
Journal Volume
33
Journal Issue
8
Series
42 refs, 2 figs, 3 tabs
Journal Page Range
p. 2623-2626
ISSN
0253-2964

INIS

Country of Publication
Korea, Republic of
Country of Input or Organization
Korea, Republic of
INIS RN
45088460
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
AROMATICS; CHLORIDES; CLEAVAGE; FURANS; PALLADIUM
Descriptors DEC
CHLORINE COMPOUNDS; ELEMENTS; HALIDES; HALOGEN COMPOUNDS; HETEROCYCLIC COMPOUNDS; METALS; MICROSTRUCTURE; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PLATINUM METALS; TRANSITION ELEMENTS