Influence of age on the frequency of sister-chromatid exchanges and X-ray-induced chromosome aberrations in muntjac

The BrdU-differential staining technique was used in a study of the frequency of sister-chromatid exchanges (SCEs) and X-ray-induced chromosome aberrations in peripheral blood lymphocytes of the same individual muntjacs. Blood was collected periodically from immediately after birth (1 day old) to the adult stage (1 year). The results showed that both the frequency of base-line SCEs and induced chromosome aberrations changed as a function of age. At a young age, the frequency of SCEs was significantly low, whereas a high frequency of chromosome aberrations was observed. But with increase in age of the individuals, an enhanced frequency of SCEs and a decreased frequency of induced chromosome aberrations were observed; and as the age advanced further, the frequencies of both SCEs and chromosomal aberrations came to a steady level. (orig.)