Application of phage display in diagnosis and therapy of cancer

Phage display is possible to screening targeted peptides, mapping organ-specific vascular molecule because of in vivo phage display. It is more remarkable that a variety of peptide ligands specific for tumor-associated makers is identified, which supplied targeted molecules for tumor diagnosis, delivery of tumor drugs and tumor vascular gene therapy. Recently, people succeed in applying the technology to tumor patients and identifying peptide motifs binding to tumor specifically. (authors)