Synthesis of piperonyl butoxide-UL-phenyl-14C

An efficient route for the preparation of 5-[1-(2-butoxyethoxy) ethoxy]methyl-6-propyl-1,3-benzodioxole-UL-phenyl-14 C (piperonly butoxide-UL-phenyl-14-C is described. The synthesis consisted of 14 steps from Ba14 CO3 and gave the title compound in overall chemical yield of 8%. A discussion of some of the possible alternate routes is provided, including the various drawbacks to these routes. The importance of order of substitution on the benzene ring to maximize yields of the title compound is emphasized. (author)