Published May 20, 1988
| Version v1
Journal article
[125I]Iodopride
- 1. Vanderbilt Univ., Nashville (USA). Dept. of Psychiatry
- 2. Vanderbilt Univ., Nashville, TN (USA). Dept. of Chemistry
- 3. Vanderbilt Univ., Nashville, TN (USA). Dept. of Radiology
Description
Substituted benzamides are currently among the most selective antagonists at dopamine D-2 receptors, and high affinity ligands have been developed by substituting halogens into the aromatic ring of the benzamides. The authors report the high affinity, stereoselective, reversible, and sodium dependent binding of a new iodine-substituted benzamide, called [125I]iodopride, to a membrane preparation from rat corpus striatum. 5 refs.; 1 figure
Additional details
Additional titles
- Subtitle (English)
- A specific high affinity radioligand for labelling striatal dopamine D-2 receptors
Publishing Information
- Journal Title
- European Journal of Pharmacology
- Journal Volume
- 150
- Journal Issue
- 1-2
- Series
- Eur. J. Pharmacol.
- Journal Page Range
- 203-205
- ISSN
- 0014-2999
- CODEN
- EJPHA
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 20026072
- Subject category
- S60: APPLIED LIFE SCIENCES; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AFFINITY; AMIDES; AROMATICS; IODINE COMPOUNDS; IODINE 125; RADIOPHARMACEUTICALS; RECEPTORS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HALOGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES