Published December 1981 | Version v1
Journal article Metadata-only

Haemopoietic recovery during radiation disease: Comments on combined-injuries

Creators

  • 1. Regensburg Univ. (Germany, F.R.). Inst. fuer Anatomie

Description

The regenerative ability of haemopoietic organs during combined radiation injuries has not been adequately investigated. Interactions among individual factors can critically influence the processes involved in haemopoietic recovery. An overview of radiation injuries is given, and a concept towards a hypothetical mode of action at the cellular level is presented. The influence which interacting factors can have on the concentration of pluripotential haemopoietic stem cells is demonstrated by results from an initial experiment. The importance of synergistic and antagonistic reactions is emphasised and commented upon. (orig.)

Abstract (German)

Die Regenerationsfaehigkeit haematopoetischer Organe waehrend einer kombinierten Strahlenschaedigung wurde noch nicht in ausreichendem Masse untersucht. Wechselwirkungen einzelner Faktoren koennen die Erholungsprozesse entscheidend beeinflussen. Es wird ein Ueberblick ueber die Formen des Strahlenschadens gegeben und ein Konzept hinsichtlich eines hypothetischen Modells der Wirkung auf zellulaerem Niveau vorgestellt. Der Einfluss der in Wechselwirkung stehenden Faktoren auf die Konzentration der pluripotenten haematopoetischen Stammzellen wird experimentell untersucht. Die Bedeutung synergistischer und antagonistischer Reaktionen wird diskutiert. (orig.)

Additional details

Publishing Information

Journal Title
Radiat. Environ. Biophys.
Journal Volume
20
Journal Issue
1
Series
Radiat. Environ. Biophys.
Journal Page Range
29-36
ISSN
0301-634X

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
13674810
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ADRENALECTOMY; BIOLOGICAL RECOVERY; BONE MARROW CELLS; FEMALES; FUNCTIONAL MODELS; GRAFTS; HEMATOPOIETIC SYSTEM; INJURIES; MALES; MICE; RADIATION INJURIES; RADIOBIOLOGY; SKIN; SYNERGISM; WHOLE-BODY IRRADIATION; WOUNDS; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGY; BODY; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MEDICINE; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; SURGERY; TRANSPLANTS; VERTEBRATES