Published 1985 | Version v1
Book Metadata-only

The development of radioactive anti-cancer drugs with high LET radiation

Creators

  • 1. Addenbrooke's Hospital, Cambridge (UK)

Description

The paper presents a method for manufacturing 6-211At-astato-MNDP. Its efficacy was tested using i.p. injections in mice which had received a previous injection of a suspension of CCL-CMT-93 adenocarcinoma cells into their flanks several weeks ago. Tumour sizes were measured daily. Survival rate revealed to be significantly increased in mice treated with 6-211At-astato-MNDP as against controls. Possible complications of treatment using this drug are discussed briefly. (MG)

Abstract (German)

Es wird eine Methode zur Herstellung von 6-211At-astato-MNDP beschrieben. Die Wirksamkeit wurde durch i.p. Injektion in Maeuse getestet, denen mehrere Wochen vorher eine Suspension von CCL-CMT-93-Adenokarzinomzellen s.c. in die Flanke injiziert worden war. Die Tumoren wurden taeglich ausgemessen. Es zeigte sich eine signifikant erhoehte Ueberlebensrate der mit 6-211At-astato-MNDP behandelten Maeuse gegenueber den unbehandelten. Die moeglichen Komplikationen einer Behandlung mit dieser Substanz werden kurz diskutiert. (MG)

Additional details

Additional titles

Original title (German)
Die Entwicklung neuer radioaktiver Pharmaka mit hoher LET-Strahlung gegen den Krebs

Publishing Information

Publisher
Thieme.
Imprint Place
Stuttgart (Germany, F.R.)
ISBN
3-13-452601-8
Imprint Title
25 years of medical radiation protection
Imprint Pagination
224 p.
Journal Volume
26
Series
Strahlenschutz in Forschung und Praxis.
Journal Page Range
p. 51-57.

Conference

Title
Radiation protection conference - 25. annual conference of Vereinigung Deutscher Strahlenschutzaerzte e.V.
Dates
15-16 Jun 1984.
Place
Freiburg im Breisgau (Germany, F.R.).

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
18032287
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ANTINEOPLASTIC DRUGS; ASTATINE 211; CARCINOMAS; CHEMICAL PREPARATION; EFFICIENCY; INJECTION; LABELLED COMPOUNDS; MICE; SIDE EFFECTS; SURVIVAL CURVES; TUMOR CELLS
Descriptors DEC
ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; ANIMALS; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTAKE; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; RODENTS; SYNTHESIS; VERTEBRATES

Optional Information

Notes
Imprint:With 56 figs., 40 tabs. ;25 Jahre medizinischer Strahlenschutz.;Rueckblick und Ausblick zur Entwicklung des Strahlenschutzes.