The new therapy strategy of glioma--STAT3 RNAi combined with traditional radiotherapy

STAT3 is an important inhibitor of apoptosis gene discovered in recent years, with a bifunction of inhibiting apoptosis and getting involved in cell cycle control. A lot of basic and clinical researches have found the relation between STAT3 gene and sensitivity to chemotherapy and radiotherapy. Researches have been focused on knocking down its expression to inhibit the growth of tumor and improve the sensitivity to radiotherapy and chemotherapy, especialy by RNAi approach. (authors)