Published 1990
| Version v1
Report
Novel alkylamine linker technology for conjugation of new hexadentate radiometallic nuclides chelating agents to 'antibodies'
- 1. Albert Einstein Coll. of Medicine, Bronx, NY (United States)
Description
A new hexadentate chelating agent, triethylenetetraaminehexaacetic acid (TTHA), has been synthesized and conjugated with proteins through alkylamine linkage, making use of the latent cross-linking potential of glycolaldehyde. It has been used to label human serum albumin with indium-111, which was subsequently used for in vivo biodistribution studies in mice
Additional details
Publishing Information
- Imprint Title
- Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
- Imprint Pagination
- 458 p.
- Journal Page Range
- p. 222-224.
- Report number
- DOE/ER/60968--1
Conference
- Title
- 8. international symposium on radiopharmaceutical chemistry.
- Dates
- 24-29 Jun 1990.
- Place
- Princeton, NJ (United States).
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 23029793
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference, Non-conventional Literature
- Descriptors DEI
- ALBUMINS; ALKYLATION; AMIDES; AMINES; BLOOD SERUM; CARBONYLS; CHELATING AGENTS; CHEMICAL PREPARATION; CHEMICAL REACTION KINETICS; CHEMOTHERAPY; GLYCYLGLYCINE; IN VIVO; INDIUM 111; LIGANDS; LIVER; MICE; MOLECULAR STRUCTURE; MONOCLONAL ANTIBODIES; NEOPLASMS; ORGANIC NITROGEN COMPOUNDS; PHENYLALANINE; RADIOIMMUNOLOGY; REDUCTION; SCHIFF BASES; TISSUE DISTRIBUTION
- Descriptors DEC
- AMINO ACIDS; ANIMALS; ANTIBODIES; AROMATICS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; IMINES; IMMUNOLOGY; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MATERIALS; MEDICINE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; REACTION KINETICS; RODENTS; SYNTHESIS; THERAPY; VERTEBRATES
Optional Information
- Secondary number(s)
- CONF-9006363--Absts.