The relationship of apoptotic index and bcl-2, bax gene expression following radiotherapy in cervical squamous cell carcinoma
- 1. Fourth Military Medical Univ., Xi'an (China). Dept. of Radiation Medicine
- 2. Fourth Military Medical Univ., Xi'an (China). Xijing Hospital, Dept. of Radiotherapy
- 3. Fourth Military Medical Univ., Xi'an (China). Xijing Hospital, Dept. of Pathology
Description
The aim was to observe bcl-2 and bax gene expression and apoptosis and to study the correlation between bcl-2 and bax gene expression and apoptotic index in the samples from patients with cervical squamous cell carcinoma following radiotherapy. Apoptosis was detected with TUNEL method. It was found that the bax gene expression and apoptotic index in cervical carcinoma significantly increased (p < 0.05 and p < 0.01, respectively) after 10 Gy irradiation compared with those of pre-therapy. However, the bcl-2 gene expression had no obvious change (p > 0.05). Authors' data suggested that the bcl-2 and bax gene cooperative expression was related un-obviously with spontaneous apoptosis, but obviously with radiation-induced apoptosis (p < 0.05, r = 0.5264) in patients with cervical squamous cell carcinoma
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research and Radiation Processing
- Journal Volume
- 20
- Journal Issue
- 1
- Journal Page Range
- p. 55-60
- ISSN
- 1000-3436
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 34022681
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- ANIMAL TISSUES; CARCINOMAS; CELL KILLING; ELECTRON MICROSCOPY; GENES; HISTOLOGICAL TECHNIQUES; MORPHOLOGICAL CHANGES; RADIOSENSITIVITY; RADIOTHERAPY; STATISTICAL DATA; UTERUS
- Descriptors DEC
- BODY; DATA; DISEASES; FEMALE GENITALS; INFORMATION; MEDICINE; MICROSCOPY; NEOPLASMS; NUCLEAR MEDICINE; NUMERICAL DATA; ORGANS; RADIOLOGY; THERAPY