Published June 2014 | Version v1
Journal article Metadata-only

Drug delivery system design and development for boron neutron capture therapy on cancer treatment

Creators

  • 1. Nuclear Science and Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC (China)
  • 2. Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC (China)
  • 3. Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan, ROC (China)
  • 4. Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan, ROC (China)

Description

We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,L-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content. - Highlights: • Herein, we have synthesized boron-modified diblock copolymer. • Bpin-PLA-PEOz, which will be served as new boron containing vehicle for transporting the boron drug. • This boron containing Bpin-PLA-PEOz micelle was low toxicity can be applied to drug delivery

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2013.12.025

Additional details

Identifiers

DOI
10.1016/j.apradiso.2013.12.025;
PII
S0969-8043(13)00625-8;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
88
Journal Issue
Complete
Journal Page Range
p. 89-93
ISSN
0969-8043
CODEN
ARISEF

Conference

Title
15. international congress on neutron capture therapy impact of a new radiotherapy against cancer
Dates
23 Aug 2005
Place
Tsukuba (Japan)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46102920
Subject category
S60: APPLIED LIFE SCIENCES; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BORON; COPOLYMERS; DELIVERY; DRUGS; ESTERS; EVALUATION; NEOPLASMS; NEUTRON CAPTURE THERAPY; PINACOL; TOXICITY; WATER
Descriptors DEC
ALCOHOLS; DISEASES; ELEMENTS; GLYCOLS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; MEDICINE; NEUTRON THERAPY; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC POLYMERS; OXYGEN COMPOUNDS; POLYMERS; RADIOLOGY; RADIOTHERAPY; SEMIMETALS; THERAPY

Optional Information

Copyright
Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.