A new rapid protocol for ²²⁶Ra separation and preconcentration in natural water samples using molecular recognition technology for ICP-MS analysis

Highlights: • The AnaLig^® Ra-01 is a new high selective resin for Ra. • This resin allows a rapid separation and preconcentration of Ra. • ²²⁶Ra signal improvement using APEX-HF connected to ICP-MS/MS. • This resin opens up possibilities for the miniaturization of Ra chemistry. - Abstract: A new rapid protocol for ²²⁶Ra separation and preconcentration in natural water samples was developed before its determination by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). For this purpose, the commercially available Ra specific resin AnaLig^® Ra-01 was used. This resin shows a high selectivity for radium in a large range of acid concentrations and no affinity or possible elution of ²²⁶Ra interfering elements. The distribution coefficients of Ra and other elements over a wide range of acid (HCl and HNO₃) concentrations were obtained. Due to the high radium selectivity, the new developed protocol uses only 50 mg of dry resin and its performance was evaluated using 100 mL of three natural waters with different ionic strengths, spiked with a known quantity of ²²⁶Ra. Radium was successfully separated and preconcentrated yielding recoveries ranging between 72% and 86%. In parallel with the characterisation of the resin sorption properties, a detailed study of polyatomic interferences was performed on our ICP-MS allowing to identify the prominent elements favouring interferences at m/z = 226. Furthermore, a ²²⁶Ra sensitivity comparison between different ICP-MS instruments and configurations was done in order to determine high sensitivity conditions for radium analysis.