Published January 2020 | Version v1
Journal article Metadata-only

Determination of ionic 68Ga impurity in radiopharmaceuticals. Major revision of radio-HPLC methods

Creators

  • 1. Russian Academy of Sciences, Moscow (Russian Federation). Frumkin Institute of Physical Chemistry and Electrochemistry
  • 2. Russian State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow (Russian Federation)
  • 3. Lomonosov Moscow State University, Moscow (Russian Federation)

Description

Determination of purity of 68Ga-radiopharmaceuticals is an extremely important part of quality control in routine clinical practice as well as during R&D of 68Ga-radiopharmaceuticals. HPLC results do not always match TLC results. This uncertainty most likely comes from nonspecific sorption of ionic 68Ga on C18 phase. The aim of this study was to develop reliable HPLC analysis procedure. It was shown that simple replacement of trifluoroacetic acid in the eluent with citric acid results into change of the results obtained using HPLC analysis. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
323
Journal Issue
1
Journal Page Range
p. 189-195
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
51044286
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
CITRIC ACID; GALLIUM 68; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; QUALITY CONTROL; RADIOPHARMACEUTICALS; THIN-LAYER CHROMATOGRAPHY
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHROMATOGRAPHY; CONTROL; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; LIQUID COLUMN CHROMATOGRAPHY; MATERIALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES

Optional Information

Notes
22 refs.