Published November 2012 | Version v1
Journal article Metadata-only

Optimization of [11C]DASB-synthesis: Vessel-based and flow-through microreactor methods

Creators

  • 1. Department of Inorganic Chemistry, University of Vienna, A-1090 Vienna (Austria)
  • 2. Radiochemistry and Biomarker Development Unit, Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna (Austria)
  • 3. Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, A-1090 Vienna (Austria)
  • 4. Department of Psychiatry and Psychotherapy, Medical University of Vienna, A-1090 Vienna (Austria)

Description

The intention for the present study was to implement a microfluidic set-up for N-11C-methylations in a flow-through microreactor device with [11C]DASB as model-compound and [11C]CH3I and [11C]CH3OTf, respectively, as 11C-methylation agents. Due to an observed "aging" effect of the 11C-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [11C]DASB was reduced (34±1 min) and RCY was increased to 45.1±4.6% (EOB; 5.2±0.95 GBq EOS). - Highlights: ► Aging effect of 11C-methylation agents observed. ► Microfluidic set-up for remote 11C-methylations questionable. ► Vessel-based approach was ameliorated. ► Radiochem. yield of [11C]DASB was increased to 45.1±4.6% (EOB; 5.2±0.95 GBq EOS).

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2012.08.001

Additional details

Identifiers

DOI
10.1016/j.apradiso.2012.08.001;
PII
S0969-8043(12)00456-3;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
70
Journal Issue
11
Journal Page Range
p. 2615-2620
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
44101068
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
AGING; CARBON 11; METHYL IODIDE; METHYLATION; OPTIMIZATION; SYNTHESIS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMICAL REACTIONS; EVEN-ODD NUCLEI; HALOGENATED ALIPHATIC HYDROCARBONS; IODINATED ALIPHATIC HYDROCARBONS; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOISOTOPES

Optional Information

Copyright
Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.