Published January 2018
| Version v1
Journal article
Synthesis and study of antimicrobial activity of quaternary ammonium benzofuroxan salts
Creators
- 1. Russian Academy of Sciences, A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center (Russian Federation)
- 2. Kazan National Research Technological University (Russian Federation)
Description
It was found that quaternary ammonium salts of benzofuroxan based on o-, m-, and p-dibromoxylenes are formed as a mixture of two tautomers. Only one bromomethyl group participates in the quaternization of benzofuroxan with different dibromoxylenes. Bacteriostatic activity of the most active mixture of tautomers was two and four times higher than the reference drug, chloramphenicol, with respect to Staphylococcus aureus 209p and Bacillus cereus 8035, correspondingly. Hemolysis of these compounds does not exceed 1%, i.e., such compounds are not toxic. Graphical abstract: .
Additional details
Identifiers
Publishing Information
- Journal Title
- Monatshefte fuer Chemie
- Journal Volume
- 149
- Journal Issue
- 1
- Journal Page Range
- p. 119-126
- ISSN
- 0026-9247
- CODEN
- MOCHAP
INIS
- Country of Publication
- Austria
- Country of Input or Organization
- Austria
- INIS RN
- 50003561
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S77: NANOSCIENCE AND NANOTECHNOLOGY;
- Descriptors DEI
- BACILLUS CEREUS; CHLORAMPHENICOL; HEMOLYSIS; MIXTURES; SALTS; STAPHYLOCOCCUS; SYNTHESIS; TOXICITY
- Descriptors DEC
- ANTIBIOTICS; ANTI-INFECTIVE AGENTS; BACILLUS; BACTERIA; CHEMICAL REACTIONS; DECOMPOSITION; DISPERSIONS; DRUGS; LYSIS; MICROORGANISMS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES
Optional Information
- Copyright
- Copyright (c) 2017 Springer-Verlag GmbH Austria