Published April 1999
| Version v1
Journal article
The pharmacokinetics of [11C]methoxy-norchloroprogabidic acid, a potential PET tracer for GABA receptors in the brain
Description
We have described the kinetic properties of [11C]methoxy-norchloroprogabidic acid, a potential radioligand for the gamma-aminobutyric acid (GABA) receptor. Early metabolism in mice was negligible. Protein binding in human plasma was 89±7%. Distribution volumes were 89.6±29.4 l whereas the elimination half-life was 41.6±14.3 min. Animal and human positron emission tomography (PET) data demonstrate limited uptake of the activity in brain tissue. Displacement studies in mice suggest a nonsignificant fraction of specific receptor binding. [11C] Methoxy-norchloroprogabidic acid is therefore unsuitable for brain PET
Additional details
Identifiers
- PII
- S0969805198001000;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 26
- Journal Issue
- 3
- Journal Page Range
- p. 323-325
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- Bulgaria
- INIS RN
- 33035893
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- AMINOBUTYRIC ACID; BLOOD PLASMA; BRAIN; CARBON 11; METABOLISM; MICE; POSITRON COMPUTED TOMOGRAPHY; PROTEINS
- Descriptors DEC
- AMINO ACIDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; CARBON ISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; RODENTS; TOMOGRAPHY; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 1999 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.