Published 1975 | Version v1
Journal article Metadata-only

DNA repair after neutron and gamma irradiation

Creators

  • 1. Oesterreichische Studiengesellschaft fuer Atomenergie G.m.b.H., Seibersdorf. Inst. fuer Biologie

Description

Because of the importance of repair processes in radiation therapy we investigated DNA repair after neutron and 60Co gamma irradiation. Unscheduled DNA synthesis was measured in spleen cells and peripheral lymphocytes by autoradiography and the rejoining of DNA strand breaks by alkaline and neutral sucrose gradient centrifugation. Up to doses of 30 krad neutrons, unscheduled DNA synthesis could be demonstrated while strand rejoining occured up to doses of 15 krad. Besides investigating DNA repair, semiconservative DNA synthesis was measured after various irradiation doses, the amount of suppression exhibiting good correlation with radiation dose

Additional details

Publishing Information

Journal Title
Stud. Biophys.
Journal Volume
50
Series
Stud. Biophys.
Journal Page Range
55-64

Conference

Title
2. annual meeting of the working group 'DNA repair and late effects' of the International Society for Research in Frontiers of Medicine.
Dates
16 Sep 1974.
Place
Budapest, Hungary.

INIS

Country of Publication
German Democratic Republic
Country of Input or Organization
German Democratic Republic
INIS RN
7228226
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; CHEMICAL RADIATION EFFECTS; COBALT 60; DNA; DOSE-RESPONSE RELATIONSHIPS; FAST NEUTRONS; GAMMA RADIATION; LYMPHOCYTES; SPLEEN; STRAND BREAKS
Descriptors DEC
ANIMAL CELLS; BARYONS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FERMIONS; HADRONS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; MINUTES LIVING RADIOISOTOPES; NEUTRONS; NUCLEI; NUCLEIC ACIDS; NUCLEONS; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; SOMATIC CELLS; YEARS LIVING RADIOISOTOPES