The dopamine D-1 receptor: biochemical and behavioral aspects
Description
3H-SCH 23390 is now widely used as D1 receptor ligand. The authors use 3H-SCH 23390 for D1 receptor binding in a previously described adenylate cyclase assay preparation of rat striatal membranes. The pharmacological characterization of the 3H-SCH 23390 binding are shown, as well as 3H-piflutixol and 3H-spiperone binding. 3H-SCH 23390 binding in vivo is examined, and the pharmacological characterization of 3H-SCH 23390 binding in vivo and in vitro are shown. The authors discuss DA-stimulated adenylate cyclase. Behavioral aspects of the D1 receptor are described. It is found that the 3H-SCH 23390 labelled D1 receptor is associated with a G-protein. Results from functional studies of the D1 receptor have indicated that there may exist both D2 coupled and non-coupled D1 receptors in the brain
Additional details
Publishing Information
- Publisher
- Plenum Press.
- Imprint Place
- New York, NY (USA)
- Imprint Title
- Neurobiology of central D - dopamine receptors
- Journal Page Range
- p. 73-92.
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18051088
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BEHAVIOR; BIOCHEMISTRY; BIOLOGICAL EFFECTS; CELL MEMBRANES; CYCLASES; DOPAMINE; LIGANDS; NERVE CELLS; NEUROLOGY; NEUROREGULATORS; PHARMACOLOGY; RADIORECEPTOR ASSAY; RATS; RECEPTORS; RETENTION; TRITIUM COMPOUNDS
- Descriptors DEC
- AMINES; ANIMAL CELLS; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; CARDIOTONICS; CARDIOVASCULAR AGENTS; CELL CONSTITUENTS; CHEMISTRY; DRUGS; ENZYMES; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LYASES; MAMMALS; MEDICINE; MEMBRANES; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; RODENTS; SOMATIC CELLS; STEROIDS; SYMPATHOMIMETICS; TRACER TECHNIQUES; VERTEBRATES