Effect of pions on the embryonal development of the mouse

It is of great interest to perform in vivo investigations for preclinical experiments of the effects on pions not only on malignant but also on healthy cells and organs. Mouse embryos at the organo-genetic stage are particularly well suited for this. Not only are they very sensitive to radiation (adequate to the present intensity of our biomedical radiation) but also particularly sensitive to LET-differences. Analyses of RBE at different points (plateau-peaks) of the ray profile, high- and low LET-radiation as well as tests with possible sensibilisators of the radiation effect with the intent to an amelioration of the cancer therapy will be considered