Published January 2007
| Version v1
Journal article
Synthesis and Characterization of Degradable Polycationic Polymers as Gene Delivery Carriers
Creators
- 1. Seoul National University, Seoul (Korea, Republic of)
- 2. Chungnam National University, Daejeon (Korea, Republic of)
Description
Biodegradable cationic poly(ester-amide) polymers were synthesized by double-monomer method, that showed excellent solubility in many organic solvents and water. Different degradation patterns were obtained by the regulation of monomer ratios and overall long period of time of DNA protection up to 12 days was shown by PicoGreen reagent assay. Good transfection profiles in the presence of serum and very low toxicity on mammalian cells may allow these polymers to become suitable for long-term gene delivery systems and therapeutic applications
Additional details
Publishing Information
- Journal Title
- Bulletin of the Korean Chemical Society
- Journal Volume
- 28
- Journal Issue
- 1
- Series
- 12 refs, 6 figs, 1 tab
- Journal Page Range
- p. 63-67
- ISSN
- 0253-2964
INIS
- Country of Publication
- Korea, Republic of
- Country of Input or Organization
- Korea, Republic of
- INIS RN
- 49099490
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- BLOOD SERUM; DNA; GENES; ORGANIC SOLVENTS; POLYMERS; REGULATIONS; SOLUBILITY; SYNTHESIS; THERAPEUTIC USES; TOXICITY
- Descriptors DEC
- BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; LAWS; MATERIALS; NONAQUEOUS SOLVENTS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; SOLVENTS; USES