Published 1998 | Version v1
Report Metadata-only

Cellular effects of the poly (ADP-ribose) polymerase inhibition associated to anti-tumoral agents and ionizing radiations

Creators

Description

A new molecule allowing the inhibition of the PARP has been studied: the PHEN an iso-quinoline derivative. On tumoral cells in culture, this molecule potentiates the anti-proliferative effects of some anti-tumoral agent commonly used. Used on splenic murine lymphocytes, the PHEN potentiates also the ionizing radiation effects. These results showed the immuno-suppressive effects of the PEHN resulting from the PARP inhibition. The author showed then the PHEN possibility to modulate some aspects of the ionizing radiation response as the proliferation, the cell cycle and the apoptosis start. (A.L.B.)

Availability note (English)

Available from Universite Louis Pasteur, Strasbourg-1, 4 rue Blaise Pascal 67070 Strasbourg Cedex (France)

Additional details

Additional titles

Original title (French)
Etude in vitro des consequences cellulaires de l'inhibition de la poly (ADP-ribose) polymerase associee a des agents antitumoraux et aux radiation ionisantes

Publishing Information

Imprint Pagination
149 p.
Report number
FRNC-TH--5114

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
34016104
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Thesis, Non-conventional Literature
Descriptors DEI
APOPTOSIS; ENZYME INHIBITORS; IMMUNOSUPPRESSION; IN VITRO; IONIZING RADIATIONS; LYMPHOCYTES; RADIOSENSITIZERS; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DRUGS; LEUKOCYTES; MATERIALS; RADIATIONS; RESPONSE MODIFYING FACTORS; SOMATIC CELLS