Published July 1984 | Version v1
Journal article Metadata-only

In vitro infectivity of irradiated Plasmodium berghei sporozoites to cultured hepatoma cells

Creators

  • 1. Biomedical Research Inst., Rockville, MD

Description

The invasion of gamma-irradiated Plasmodium berghei sporozoites into cultured hepatoma cells and their transformation into trophozoites was similar to invasion and transformation of non-irradiated sporozoites. However, trophozoites from irradiated sporozoites did not further develop into schizonts, but persisted within the cells for up to 3 days. Sporozoite surface protective antigen was present in trophozoites from irradiated and non-irradiated sporozoites, suggesting that hepatocyte antigen processing may contribute to the induction of anti-malarial immunity

Additional details

Publishing Information

Journal Title
Am. J. Trop. Med. Hyg.
Journal Volume
33
Journal Issue
4
Series
Am. J. Trop. Med. Hyg.
Journal Page Range
544-547
ISSN
0002-9637

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
16049871
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; INFECTIVITY; LIFE CYCLE; PLASMODIUM; SOMATIC CELLS
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; INVERTEBRATES; MICROORGANISMS; PARASITES; PROTOZOA; RADIATION EFFECTS