MRI thermometry in phantoms by use of the proton resonance frequency shift method: application to interstitial laser thermotherapy

In this work the temperature dependence of the proton resonance frequency was assessed in agarose gel with a high melting temperature (95 deg. C) and in porcine liver in vitro at temperatures relevant to thermotherapy (25-80 deg. C). Furthermore, an optically tissue-like agarose gel phantom was developed and evaluated for use in MRI. The phantom was used to visualize temperature distributions from a diffusing laser fibre by means of the proton resonance frequency shift method. An approximately linear relationship (0.0085 ppm deg. C-1) between proton resonance frequency shift and temperature change was found for agarose gel, whereas deviations from a linear relationship were observed for porcine liver. The optically tissue-like agarose gel allowed reliable MRI temperature monitoring, and the MR relaxation times (T1 and T2) and the optical properties were found to be independently alterable. Temperature distributions around a diffusing laser fibre, during irradiation and subsequent cooling, were assessed with high spatial resolution (voxel size = 4.3 mm3) and with random uncertainties ranging from 0.3 deg. C to 1.4 deg. C (1 SD) with a 40 s scan time. (author)