A novel electrochemical determination for the anti-osteoporosis drug (alendronate sodium) and its application for corrosion monitoring of surgical 316 L SS bone implant

Low cost and simply produced electrochemical silver nanoparticles modified graphene oxide (SNMGO) sensor was constructed to monitor 1 mM Alendronate sodium (ALN) drug. The corrosion behavior of surgical 316 L stainless steel (SS) as bone implant in simulated body fluid (pH 7.4) coated with a novel nano-composite coating, containing Chitosan (CS), TiO₂ nanoparticles (TO) and multi-walled carbon nanotube (CNT) was monitored. Cyclic voltammetry, Differential pulse voltammetry, Potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) measurements were used in ALN electrochemical determination using SNMGO sensor and to detect the corrosion behavior of nano-composite coat (CS/TONP/CNT) in simulated body fluid (SBF). Scanning electron microscope (SEM) and energy dispersive X-Ray analysis (EDX) techniques were done to confirm both sensor and corrosion results. - Highlights: • CPE modified with AgNPs and GO were done for alendronate determination. • A novel CS/TONP/CNT Nano-composite coat performed on surgical 316L SS implant. • SNMGO sensor used to monitor the corrosion by determining the drug peak current with time.