Published 1986 | Version v1
Journal article Metadata-only

Influence of immunomodulators on the lymphokine secretion of irradiated lymphocytes

Creators

  • 1. Polska Akademia Nauk, Wroclaw. Inst. Immunologii i Terapii Doswiadczalnej
  • 2. Rostock Univ. (German Democratic Republic)

Description

Spleen lymphocytes derived from guinea pigs loose their ability to secrete lymphokines induced by Con A after treatment with irradiation (500 and 750 mC/kg). In the presence of the immunomodulators isoprinosine, levamisole and the thymosine-like factor TFX the lymphocytes are again capable of secreting lymphokines. After treatment with immunomodulators in dosages between 10 and 100 μg/ml the migration inhibition activity for macrophages and the chemotactic activity for polymorphonuclear granulocytes produced by lymphocytes were restored. (author)

Additional details

Additional titles

Original title (German)
Der Einfluss von Immunmodulatoren auf die Lymphokinsekretion strahlengeschaedigter Lymphozyten

Publishing Information

Journal Title
Allerg. Immunol.
Journal Volume
32
Journal Issue
1
Series
Allerg. Immunol.
Journal Page Range
57-64
ISSN
0323-4398
CODEN
ALIMC

INIS

Country of Publication
Germany
Country of Input or Organization
German Democratic Republic
INIS RN
17054571
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL REPAIR; CELL CULTURES; DRUGS; GUINEA PIGS; IMMUNITY; LYMPHOCYTES; LYMPHOKINES; SECRETION; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; LEUKOCYTES; MAMMALS; MATERIALS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES