Published April 1990
| Version v1
Journal article
Rapid synthesis of radiolabeled phenylethanolamine
- 1. Kentucky Univ., Lexington, KY (United States). College of Pharmacy
Description
A method for the rapid synthesis of [14C]-phenylethanolamine (PEOH) amenable to the preparation of [11C]-PEOH was developed under anhydrous conditions. Reaction of benzaldehyde with [14C]-NaCN in the presence of crown ethers in THF yielded [14C]-cyanohydrin which was reduced to [14C]-PEOH with borane in the same solvent. The overall chemical and radiochemical yields were 33%. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 28
- Journal Issue
- 4
- Journal Page Range
- p. 373-376.
- ISSN
- 0362-4803
- CODEN
- JLCRD4
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 26009582
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AMINES; AROMATICS; BENZALDEHYDE; BRAIN; CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; LABELLING; RADIOPHARMACEUTICALS
- Descriptors DEC
- ALDEHYDES; BODY; CARBON COMPOUNDS; CENTRAL NERVOUS SYSTEM; DRUGS; LABELLED COMPOUNDS; MATERIALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; SYNTHESIS