Published July 1983 | Version v1
Journal article

Artificial hyperglycemia as a factor potentiating selectively an anti-tumoral radiation effect

Creators

  • 1. Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Nejrokhirurgii

Description

An important peculiarity of tumoral cells is their ability for intensive glycolysis. Potential biochemical mechanisms of this phenomenon are considered in the review. A tumoral process is closely connected with the changes in glucose metabolism in an organism. Therefore artificial hyperglycemia (AH) can be an instrument for intervention into tumoral cell energetics. Many experimental data show an increase of glucose consumption at AH. Long-term AH causes a reduction of tumor pH. Various view points on AH antitumoral effect mechanism are considered. Data on changes in a sound organism in case of long-term AH are given. It has been found that AH does not cause irreversible changes on the part of organs and systems of the organism. Experimental data on a possibility of using short-term hyperglycemia as a factor selectively potentiating antitumoral radiation effect are considered

Additional details

Additional titles

Original title (Russian)
Iskusstvennaya giperglikemia kak faktor, izbiratel'no usilivayushchjj protivoopukholevyj radiatsionnyj ehffekt

Publishing Information

Journal Title
Med. Radiol.
Journal Volume
28
Journal Issue
7
Journal Series
Med. Radiol.
Journal Page Range
66-69
ISSN
0025-8334