Artificial hyperglycemia as a factor potentiating selectively an anti-tumoral radiation effect
Description
An important peculiarity of tumoral cells is their ability for intensive glycolysis. Potential biochemical mechanisms of this phenomenon are considered in the review. A tumoral process is closely connected with the changes in glucose metabolism in an organism. Therefore artificial hyperglycemia (AH) can be an instrument for intervention into tumoral cell energetics. Many experimental data show an increase of glucose consumption at AH. Long-term AH causes a reduction of tumor pH. Various view points on AH antitumoral effect mechanism are considered. Data on changes in a sound organism in case of long-term AH are given. It has been found that AH does not cause irreversible changes on the part of organs and systems of the organism. Experimental data on a possibility of using short-term hyperglycemia as a factor selectively potentiating antitumoral radiation effect are considered
Additional details
Additional titles
- Original title (Russian)
- Iskusstvennaya giperglikemia kak faktor, izbiratel'no usilivayushchjj protivoopukholevyj radiatsionnyj ehffekt
Publishing Information
- Journal Title
- Med. Radiol.
- Journal Volume
- 28
- Journal Issue
- 7
- Journal Series
- Med. Radiol.
- Journal Page Range
- 66-69
- ISSN
- 0025-8334
INIS
- Country of Publication
- Russian Federation
- Country of Input or Organization
- USSR
- INIS RN
- 15035798
- Subject category
- RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Quality check status
- Yes
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; EXPERIMENTAL NEOPLASMS; GLUCOSE; HYPERGLYCEMIA; INJECTION; INSULIN; LABORATORY ANIMALS; RADIOTHERAPY; RESPONSE MODIFYING FACTORS; REVIEWS;
- Descriptors DEC
- ALDEHYDES; ANIMALS; BIOLOGICAL EFFECTS; CARBOHYDRATES; DISEASES; DOCUMENT TYPES; HEXOSES; HORMONES; INTAKE; MEDICINE; MONOSACCHARIDES; NEOPLASMS; ORGANIC COMPOUNDS; PEPTIDE HORMONES; RADIATION EFFECTS; SACCHARIDES; THERAPY;