Establishment of a better pig model of severe acute pancreatitis

Objective: To establish a new severe acute pancreatitis (SAP) pig model for evaluating enteral administration therapy. Methods: Eight tai-lake plum-mountain pigs were randomized into the SAP group(n=4) and the control group(n=4). In anaesthetised eight pigs were orthophoric inserted a nasojejunal catheter. In the SAP group the pancreatic duct was cannulated and taurocholic acid was infused to induce severe acute pancreatitis. Pigs in the control group were cannulated alone and served as the controls. Temperature, bowel sounds, serum amylase, computed tomography (CT) scores and histologic examination were compared between the two groups, to confirm that whether pancreatitis model was established or catheter was inserted. Results: Compared with the control group, SAP group serum amylase was obviously increased (P<0.05). Both CT and histologic examination demonstrated that severe acute pancreatitis model was established and nasojejunal catheter was inserted successfully. Conclusion: It is a simple, noninvasive, repeatable model of enteral nutrition and administration through intestinum in pancreatitis treatment. (authors)