Quantification of specific growth patterns and frequency of the empty sella phenomenon in growth hormone-secreting pituitary adenomas

Highlights: • The frequcency of an empty sella is increased in acromegaly patients. • GH-secreting adenomas show a quantificable, downward-directed growth. • Hypothetically, this growth pattern reflects speciric bone remodeling processes. • Craniometric measures can be used for pituitary adenoma differentiation. - Abstract: Purpose: To assess and quantify the prevalence and co-occurence of a sellar floor lowering and empty sella phenomenon in patients with GH (growth hormone)-secreting pituitary adenoma.