Regional myocardial perfusion analysis with99mTc-SQ 30217 (teboroxime) using dynamic SPECT

It has been considered that a new promising myocardial imaging agent, Tc-99m teboroxime, may be of limited value in conventional SPECT imaging acquisition because of its rapid myocardial clearance. The present study was thus designed to devise a method for reconstructing SPECT images in a voluntary time, as well as analysing dynamic SPECT images. For these purposes, dynamic acquisition method with three-headed SPECT system was used, that allowed highly sensitive data acquisition. Clearance times from phase I and II were 2.8 min and 58 min, respectively. Regarding clearance from infarcted areas, there was no significant difference between myocardial segments. Although defect site of Tl-201 myocardial scan coincided with that of Tc-99m teboroxime, uptake of Tc-99m teboroxime in the inferior segment tended to be higher than that of Tl-201. (N.K.)