Published March 1988
| Version v1
Journal article
An improved synthesis of [5'-3H]-3'-azido-3'-deoxythymidine, tritiated Zidovudine
Creators
- 1. Burroughs Wellcome Co., Research Triangle Park, NC (USA). Wellcome Research Labs.
Description
[5'-3H]-3'-Azido-3'-deoxythymidine (3) was prepared at a specific activity of 14.0 Ci/mmol by a two-step synthetic sequence involving controlled oxidation of the unlabelled compound (1) to the 5'-aldehyde (2) followed by reduction with [3H]-NaBH4. Purification was performed by preparative TLC. The radiochemical purity was 99.2%. (author)
Additional details
Publishing Information
- Journal Title
- J. Labelled Compd. Radiopharm.
- Journal Volume
- 25
- Journal Issue
- 3
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 277-280
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 19071443
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- AZIDO COMPOUNDS; CHEMICAL PREPARATION; LABELLING; RADIOIMMUNOASSAY; RADIOPHARMACEUTICALS; REDUCTION; THYMIDINE; TRITIUM
- Descriptors DEC
- AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; IMMUNOASSAY; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; NUCLEOSIDES; NUCLEOTIDES; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RIBOSIDES; SYNTHESIS; TRACER TECHNIQUES; YEARS LIVING RADIOISOTOPES