Published August 1990 | Version v1
Journal article Metadata-only

[82Br]cisplatin derivative: a potential biological model for cisplatin

Creators

  • 1. Manchester Univ. (UK)
  • 2. Manchester Univ. (UK). Inst. of Science and Technology

Description

The complex cis-[Pt(NH3)282Br2] has been prepared as a possible model for cisplatin, cis-[Pt(NH3)2Cl2]. The stability of cis-[Pt(NH3)282Br2] was investigated in 0.9% saline solution and sterile water. In both cases the 82Br label was rapidly displaced in the first hour (t1/2 = 73 min and 96 min respectively). Thus, cis-[Pt(NH3)282Br2] cannot be used for determining the fate of the labile ligands of cisplatin. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
28
Journal Issue
8
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
971-976
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
22018567
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ANTINEOPLASTIC DRUGS; BROMINE 82; CHEMICAL PREPARATION; LABELLING; LIGANDS; PLATINUM COMPLEXES; RADIOPHARMACEUTICALS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BROMINE ISOTOPES; COMPLEXES; DAYS LIVING RADIOISOTOPES; DRUGS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TRANSITION ELEMENT COMPLEXES