Published November 1975 | Version v1
Journal article Metadata-only

Effect of extreme hypoxia on the repair of DNA single-strand breaks in mammalian cells

Creators

  • 1. Univ. of California, San Francisco

Description

About 20 percent of the single-strand breaks produced by x rays in V79 Chinese hamster cells under extremely hypoxic conditions remain unrepaired after 1 hr at 370C. The corresponding figure is only 10 percent for cells irradiated under moderately hypoxic (0.2 μM) or aerobic conditions (200 μM). The initial number of breaks produced per unit dose is identical for extremely hypoxic and moderately hypoxic cells and is about four times greater for aerobic cells. Because split-dose recovery proceeds under aerobic and moderately hypoxic conditions and is inhibited only under extremely hypoxic conditions, the split-dose recovery phenomenon may be related to the unrepaired component of single-strand breaks

Additional details

Identifiers

DOI
10.2307/3574263;

Publishing Information

Journal Title
Radiation Research
Journal Volume
64
Journal Issue
2
Series
Radiat. Res.
Journal Page Range
256
ISSN
0033-7587

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
7248418
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANIMAL CELLS; ANOXIA; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; CELL CULTURES; DNA; HAMSTERS; IRRADIATION; RADIOSENSITIVITY; STRAND BREAKS; X RADIATION
Descriptors DEC
ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES

Optional Information

Notes
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