Published November 1986 | Version v1
Journal article Metadata-only

Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation

Creators

  • 1. Harvard Univ., Cambridge, MA

Description

Escherichia coli devoid of glutathione (because of transposon insertions in the gshA gene) has normal resistance to H2O2, cumene hydroperoxide, heat, or ionizing radiation. Intracellular glutathione thus does not protect E. coli from such lethal oxidative damage. The use of gshA::Tn10 mutants also revealed a glutathione-independent, H2O2-inducible resistance to N-ethylmaleimide

Additional details

Publishing Information

Journal Title
J. Bacteriol.
Journal Volume
168
Journal Issue
2
Series
J. Bacteriol.
Journal Page Range
1026-1029
ISSN
0021-9193
CODEN
JOBAA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18041097
Subject category
S61: RADIATION PROTECTION AND DOSIMETRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL EFFECTS; BIOLOGICAL FUNCTIONS; BIOLOGICAL RADIATION EFFECTS; ESCHERICHIA COLI; GAMMA RADIATION; GLUTATHIONE; HYDROGEN PEROXIDE; HYPERTHERMIA; MUTATIONS; RADIOSENSITIVITY; SENSITIVITY; TOXICITY
Descriptors DEC
BACTERIA; BODY TEMPERATURE; DRUGS; ELECTROMAGNETIC RADIATION; HYDROGEN COMPOUNDS; IONIZING RADIATIONS; MICROORGANISMS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PEPTIDES; PEROXIDES; POLYPEPTIDES; PROTEINS; RADIATION EFFECTS; RADIATIONS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS