Published April 1995
| Version v1
Journal article
A recurrent human papillomavirus integration site at chromosome region 12q14-q15 in SW756 and SK-v cell lines derived from genital tumors
- 1. Institut Curie, 75 - Paris (France)
- 2. Institut Pasteur, 75 - Paris (France)
Description
The SW756 cell line, derived from an invasive cancer of the uterine cervix, harbours integrated human papillomavirus (HPV) 18 DNA sequences which have been located in chromosome band 12q13. By in situ hybridization experiments with tritiated and digoxigenin-labelled HPV18 probes on R-banded chromosomes, we now localize the integrated viral sequences in 12q14-q15. Interestingly, we have previously localized integrated HPV16 sequences in the same chromosomal region in SK-v cells, derived from a pre-invasive vulvar neoplasia. The chromosomal region 12q14-q15 could thus correspond to a preferential site for the integration of HPV DNA in genital tumors. (authors). 29 refs., 2 figs
Additional details
Publishing Information
- Journal Title
- Comptes Rendus de l'Academie des Sciences. Serie 3
- Journal Volume
- 318
- Journal Issue
- 4
- Journal Page Range
- p. 475-478.
- ISSN
- 0764-4469
- CODEN
- CRASEV
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 27007881
- Subject category
- S60: APPLIED LIFE SCIENCES; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARCINOMAS; DNA SEQUENCING; HUMAN CHROMOSOME 12; HYBRIDIZATION; IN-SITU PROCESSING; TRITIUM; TUMOR CELLS; UROGENITAL SYSTEM DISEASES; VIRUSES
- Descriptors DEC
- ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHROMOSOMES; DISEASES; HUMAN CHROMOSOMES; HYDROGEN ISOTOPES; ISOTOPES; LIGHT NUCLEI; MICROORGANISMS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORE PROCESSING; PARASITES; RADIOISOTOPES; STRUCTURAL CHEMICAL ANALYSIS; YEARS LIVING RADIOISOTOPES